JAMA: The Journal of the American Medical Association
Copyright 1999 by the American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use. American Medical
Association, 515 N. State St, Chicago, IL 60610.

There is now significant literature showing that psychological stress can
down-regulate various aspects of the cellular immune response. It is also
established that communication between the central nervous system and the immune
system occurs through bidirectional signals linking the nervous, endocrine, and
immune systems. Psychological stressors affect the immune system by disrupting
these networks. In this overview, we discuss the implications of psychological
stress-associated immune modulation and risk for infectious disease.

New Scientific Discoveries Continue to Support Transfer Factors

Rockefeller University Scientists Uncover New Findings on Natural Killer Cells
SANDY, UT (June 25, 2004) — In two separate papers published in the February issue of The Journal of Immunology, Christian Munz, Ph.D. and Guido Ferlazzo, Ph.D. of Rockefeller University discovered that natural killer cells in the body need to acquire the ability to recognize and destroy infected cells and “…have to be nurtured. Their ability to destroy tumor and infected cells is not present at birth.”

Munz and Ferlazzo are also beginning to understand that natural killer cell function can be “tailored” or “targeted” toward specific healthy immune support activity.

Commenting on this discovery, David Lisonbee, CEO of 4Life stated, “This is a significant discovery that validates what 4Life has been teaching for the past six years. 4Life® Transfer Factor™ is effective because it gives the natural killer cells the information necessary to recognize harmful cells that are attacking the body. Since natural killer cells need to be nurtured or tutored and are not born with the knowledge of which cells are harmful, it is easy to see why 4Life Transfer Factor is enjoying the tremendous success and recognition that it has received.”

Mr. Lisonbee went on to say, “It was very interesting to me that Munz and Ferlazzo have identified a need to start targeting natural killer cell function to attack specific diseases or health threats. This has been the vision behind the targeted line of 4Life Transfer Factor products. We are now targeting healthy heart function, brain function and healthy glucose levels because of their relationship to inflammation and health threats. The reports we have received from doctors and customers have exceeded our expectations.”

“Our original line of 4Life Transfer Factor products was proven to be 10 to 20 times more effective than products such as Echinacea or whole cow colostrum. Our new 4Life Transfer Factor Plus Advanced Formula is almost twice as effective as the former 4Life Transfer Factor product. The remarkable new 4Life Transfer Factor products will put 4Life head and shoulders above other immune support products and give our distributors a tremendous advantage in the market,” concluded Mr. Lisonbee

4Life Unveils Unprecedented Results for Natural Immune Enhancing Products!

SANDY, UT (May 21, 2004) — Today, in an historic announcement at its bi-annual convention held in Salt Lake City, Utah, 4Life unveiled the next generation of 4Life Transfer Factor™ products. 4Life Transfer Factor Advanced Formula products have been significantly enhanced in their effectiveness through the combination of both cow colostrum and chicken egg yolk transfer factor sources. Using blinded, independent cytotoxicity testing, human natural killer cells activated by various transfer factor blends from chicken eggs and cow colostrum; were combined with human cancer cells. Through this process, the most effective blend for the most potent kill rate was determined. Results of this in-depth study indicate that 4Life Transfer Factor Advanced Formula boosts natural killer (NK) cell activity by 283% and 4Life Transfer Factor Plus Advanced Formula logged a remarkable 437% increase.

Commenting on this remarkable accomplishment, David Lisonbee, CEO of 4Life stated, “This is perhaps the most significant announcement in the history of 4Life. In natural killer cell testing, our original line of 4Life Transfer Factor products was proven to be 10 to 20 times more effective than products such as Echinacea or cow colostrum.  Our new 4Life Transfer Factor Plus Advanced Formula is almost twice as effective as the former 4Life Transfer Factor product.  Further clinical testing that is being conducted in Russia is providing astounding results that will be made available at a later date.  This remarkable new 4Life Transfer Factor product will put 4Life head and shoulders above other immune enhancing products and give our distributors a tremendous advantage in the market.”

“4Life owns exclusive patents for the next 16 years on transfer factors derived from chicken egg sources. A proprietary process of incubation of NK-activated chicken eggs allows 4Life to be able to control the effectiveness of the transfer factors obtained from egg yolks,” stated Dr. William Hennen, Chief Scientific Officer of 4Life. “It required painstaking work for many years on the part of numerous scientists to arrive at this remarkable achievement. We have many people to thank for their tireless effort in developing the most effective immune enhancing product available.”

The new 4Life Transfer Factor Advanced Formula products are now available for shipment to 4Life Distributors and customers in several countries. Efforts are being made to register the new products in many of the 26 countries now serviced by 4Life Distributors

American Medical Review Features 4Life Transfer Factor^tm

SANDY, UT (January 12, 2004) —In a company wide conference call to distributors held this evening, it was announced that the American Medical Review program that is made for national TV broadcasting, featuring 4Life Transfer Factor is now available to 4Life Distributors. Morley Safer is host of this  Transfer Factor documentary that includes product spokespersons William Hennen PhD, Chief Scientific Officer of 4Life and Richard Bennett PhD, member of the 4Life Medical Advisory Board. The American Medical Review program is expected to air numerous times over the course of this year on various Public Broadcast Stations and health related channels.

David Lisonbee , CEO of 4 Life remarked, “The American Medical Review presents 4Life as a company that is making a significant contribution to personal healthcare and as a company that has risen to meet the health and wellness challenges of today. This represents a great tool for 4Life Independent Distributors to use in business presentations. With such credible endorsements and scientifically based products together with being recognized as one of the fastest growing companies in America , the 4Life opportunity is unparalleled in its potential.”

4Life has combined two very powerful marketing pieces together in one DVD, the Compound Opportunity video and The American Medical Review. As a bonus, the Compound Opportunity segment of the DVD can be viewed in both English and Spanish in order to help distributors build an international organization. The DVD format will enable distributors to personalize their presentation style by pausing for conversation or cueing quickly to desired segments.

4Life's Transfer Factor product safety statement

4Life shares the concerns of many with regard to the recent announcement of the first incidence of Bovine Spongiform Encephalopathy (BSE or Mad Cow Disease) reported in the United States.  Naturally questions have arisen as result of this announcement about the procedures 4Life follows to ensure the safety of its Transfer Factor products.  Our primary focus is your health and safety and you can rest assured that 4Life adheres to a strict set of guidelines intended to ensure the quality of the products we offer. 

All 4Life Transfer Factor products are obtained from licensed Grade A dairies that are registered with and monitored by the United States Department of Agriculture (USDA).  These modern state-of-the-art facilities follow stringent Good Manufacturing Practices and are part of an elite group who have been registered to export milk products into the European Union (EU) following the strict regulation changes that were put into effect after January 1, 2001.  A press release by the Health and Consumer Protection Directorate-General of the EU said, "The Scientific Steering Committee (SSC) sees no evidence for the transmission of BSE through milk (emphasis and italics added).  Hence, there is no reason for restriction on the use of milk stated the 16 independent scientists."

Additionally, the Food and Drug Administration (FDA) stated, "The scientific data indicated that milk from BSE cows does not transmit BSE.  National and international public health organizations have consistently stated that milk and milk products are safe regardless of whether the country producing them has had cases of BSE."

Dr. William Hennen, Chief Scientific Officer of 4Life Research states, "We take great care to provide products that are safe and beneficial to our friends, customers and families.  BSE (mad cow disease) has been known for more than ten years and we have evaluated all potential risk factors thoroughly.  There is no scientific evidence that milk or colostrum pose any risk for BSE transmission.  Nor were there any cases of BSE transmission between infected cows and their suckler calves.  The most recent data continues to confirm that milk and colostrum are safe and free of BSE."

You can feel confident that 4Life will continue to monitor this situation closely and to communicate any additional information on a timely basis.

The Germ Survival Guide Recommends Transfer Factor

SANDY, UT (December 8, 2003) - 4Life Research, LC. is pleased announced today that its flagship products, Transfer Factor^tm and Transfer Factor PlusⓇ have been highly praised in The Germ Survival Guide, a new book written by Kenneth A. Bock, M.D., Steven J. Bock, M.D., and Nancy Faass, MSW, MPH. and published by McGraw Hill.  The book is designed to give families and individuals preventative strategies to use to protect against germs and environmental threats. 

Transfer Factor^tm and Transfer Factor Plus ^TM are extolled in the book as an effective way to optimize immune system function so that personal immunity is at its best in the face of a variety of health threats. 

Transfer Factor and Good Health Maintenance - David Lisonbee, CEO of 4Life Research said, "We are very pleased to have members of the medical community recognize Transfer Factor as a key strategy in maintaining good health.  Transfer Factor is being used and recommended by medical and health practitioners - world wide."

4Life Products Listed in Physicians Desk Reference                                                                                 

SANDY, UT (August 13, 2003) 4Life Research (4Life) announced today that Transfer Factor Cardio and Transfer Factor Plus are now listed in the Physicians Desk Reference for Nonprescription Drugs and Dietary Supplements (PDR).  The PDR has been in use for over 57 years and is recognized as an unbiased reference source for physicians to research and recommend drugs and supplements. 

The Nutritional Supplements Edition of the PDR lists Food and Drug Administration approved over-the-counter medicines and also includes a section on dietary supplements, vitamins and herbal remedies.  The Transfer Factor Cardio and Transfer Factor Plus listings appearing on page 805 include a full description of the two products, a summary of research, directions for use and contact information for the company. 

David Lisonbee, Chief Executive Officer of 4Life, commented, "4Life has taken a significant step by listing its tested and proven products in this important reference source.  Our distributors can have the assurance that the same products they are recommending to family and friends are referenced and recommended by doctors and health care practitioners.  This is especially important in foreign countries that rely heavily upon reputable sources such as the PDR when recommending products to prospective customers.  As 4Life continues to grow domestically and in new foreign markets, our PDR entries will create immediate credibility for our new distributors to rely upon." 

4Life is aggressively growing in 16 countries, with plans of continued foreign expansion.  This growth is part of the ongoing mission of the company to "Take Transfer Factor to the World."

4Life Research is the world's foremost manufacturer and marketer of Transfer Factor products that are derived from eggs, as well as cow colostrum (first milk).  4Life Research holds exclusive patents on these products and processes. 

The Importance of A Healthy Immune System as Your Best Defense

4Life Research, Sandy, Utah, USA - April 25, 2003 - During the past few weeks there have been numerous media reports about a new and highly contagious form of atypical pneumonia that is being called Severe Acute Respiratory Syndrome or SARS. 

Researchers have recently identified the cause as a new strain of corona virus.  SARS is just the latest in a series of previously unidentified infectious agents that are causing serious concerns around the world.  They spread, virtually unimpeded, from one continent to another through international air travel.  While there has been disagreement among experts as to the etiology of the disease, there has always been overwhelming agreement that one's immune system provides the best defense against contracting SARS or any other of these new infectious agents.  4Life Research, the exclusive US supplier of patented Transfer Factor products, has endorsed this philosophy since its inception.  4Life's research and development focus has always been that the key to staying healthy and resisting disease rests with our immune system. 

Several noted doctors and researchers involved with 4Life Research and Transfer Factor have recently made the following statements:

"The unfolding events surrounding Severe Acute Respiratory Syndrome, (SARS) is yet another painful reminder that we live in a crowded world where continents are only a plane ride away.  The SARS epidemic is only one of an ongoing series of new emerging diseases.  Our best global and personal strategy is to do all in our power to ensure and support our unique abilities of disease resistance and immunity"  Richard Bennett, PhD.

"It is increasingly clear that as the world becomes a smaller place, with viruses and other pathogens traveling with great ease, we now face a unique situation.  Simply put, we are now, and will continue to be more exposed to challenges to our health.  However, nature has already provided the immune system as our defense to microbes found in our environment.  The degree to which we are able to educate our immune systems to recognize invaders will help determine our ability to cope with health challenges.  I urge all people to pay attention to those things that affect their immune systems."  William J. Hennen, Ph. D.

4Life Research ^TM Awarded Exclusive Patent for Egg-Derived Transfer Factor

October 22, 2002 - 4Life Research, LC announced today it has been awarded the exclusive patent (US Patent #6,468,534) for extracting transfer factors from the eggs of non-mammalian sources.  "This original patent protects 4Life's continued exclusivity in the transfer factor market and secures its opportunity for expanded research and development with transfer factors and immune health," said Chief Scientific Officer at 4Life ResearchⓇ, William Hennen, Ph.D.

Transfer Factors are a scientifically recognized delivery system for transferring immune system advantages from one species to another.  In the patented process owned by 4LifeⓇ, these tiny molecules are extracted from eggs and then transferred to humans in the form of a nutritional supplement. 

4Life Research has already established itself as the recognized leader of Transfer Factor products, with products for adults, children, and even animals.  In addition to its revolutionary products, Transfer FactorⓇ and Transfer Factor Plus, 4Life recently released a new product, TF Cardio, to provide targeted Transfer Factor support for the entire cardiovascular system.  4LifeⓇ also uses a patent for extracting Transfer Factors from bovine colostrum (US Patent #4,816,563).

4LifeⓇ currently operates in the United States, Japan, New Zealand and Australia, with several other international markets opening soon.  According to David Lisonbee, Chief Executive Officer of 4Life Research, "This historical announcement further cements 4Life's growing presence in the dietary supplement marketplace, both domestically and internationally.  We're excited to continue developing innovative and effective immune-enhancing products with this remarkable molecule, Transfer Factor."